![]() ![]() The accuracy of the algorithm is evaluated through verification of the distribution of predicted cases, case-by-case phylogenetic analysis and comparisons with predictions from other projects using independent methods. The algorithm works with pairwise distance estimates, rather than computationally expensive and error-prone tree-building methods. We present an algorithm for the detection of non- orthologs that arise by mistake in current orthology classification methods based on genome-specific best hits, such as the COGs database. ![]() Detecting non- orthology in the COGs database and other approaches grouping orthologs using genome-specific best hits.Äessimoz, Christophe Boeckmann, Brigitte Roth, Alexander C J Gonnet, Gaston HĬorrect orthology assignment is a critical prerequisite of numerous comparative genomics procedures, such as function prediction, construction of phylogenetic species trees and genome rearrangement analysis.
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